Mycobacterium tuberculosis Des protein: an immunodominant target for the humoral response of tuberculous patients.
نویسندگان
چکیده
The phoA gene fusion methodology permitted the identification of a new Mycobacterium tuberculosis exported protein, Des. This protein has significant sequence similarities to plant acyl-acyl carrier protein desaturases, which are enzymes involved in general fatty acid biosynthesis as well as in mycolic acid biosynthesis in mycobacteria. As shown by Western blot and enzyme-linked immunosorbent assay experiments, the Des protein is a major B-cell antigen that was recognized by all the tuberculous M. tuberculosis- and M. bovis-infected human patients tested.
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ورودعنوان ژورنال:
- Infection and immunity
دوره 65 7 شماره
صفحات -
تاریخ انتشار 1997