Direct renal effects of a fructose-enriched diet: interaction with high salt intake.
نویسندگان
چکیده
Consumption of fructose has increased during the last 50 years. Excessive fructose consumption has a detrimental effect on mammalian health but the mechanisms remain unclear. In humans, a direct relationship exists between dietary intake of added sugars and increased risk for cardiovascular disease mortality (52). While the causes for this are unclear, we recently showed that fructose provided in the drinking water induces a salt-dependent increase in blood pressure in Sprague-Dawley rats in a matter of days (6). However, little is known about the effects of fructose in renal salt handling and whether combined intake of high fructose and salt can lead to salt-sensitive hypertension before the development of metabolic abnormalities. The long-term (more than 4 wk) adverse effects of fructose intake on renal function are not just due to fructose but are also secondary to alterations in metabolism which may have an impact on renal function. This minireview focuses on the acute effect of fructose intake and its effect on salt regulation, as they affect blood pressure.
منابع مشابه
Direct Renal effects of a fructose-enriched diet: interaction with high
3 Direct Renal effects of a fructose-enriched diet: interaction with high 4 salt intake 5 6 7 Gustavo R. Ares1 and Pablo A. Ortiz1,2 8 9 10 Corresponding Author: Pablo A. Ortiz, Ph.D. 11 1) Hypertension and Vascular Research Division 12 Department of Internal Medicine 13 Henry Ford Hospital 14 2799 West Grand Blvd 15 Detroit, MI 48202 16 Phone: 313-916-7164 17 Fax: 313-916-1479 18 E-mail: porti...
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متن کاملاثر رژیم غذایی حاوی فروکتوز بالا بر روی پروفیل لیپیدی پلاسما و استرس اکسیداتیو قلب و کلیه در موش صحرایی
Z Vahabzadeh [1] , MSC MH Khadem Ansari [2] , PhD A Abolfathi [3] , PhD A Safaian [4] , MSC F Bozorgi Gharaghoyunlou [5] , PhD Received: 19 July, 2007 Accepted: 10 Sep, 2008 Abstract Background & Aims: Although there is little evidence that modest amounts of fructose have detrimental effects on carbohydrate and lipid metabolisms, larger doses of fructose have been associated with numerous ...
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ورودعنوان ژورنال:
- American journal of physiology. Regulatory, integrative and comparative physiology
دوره 309 9 شماره
صفحات -
تاریخ انتشار 2015