Abundance of pseudoknots: theory and observation
نویسندگان
چکیده
The pseudoknot fold is often seen in auto-catalytic RNA and in viruses. The relative probabilities of different pseudoknot folds predicted by a statistical-mechanical theory is consonant with a database of known folds. We extend that result to estimate the abundance of pseudoknot folds in RNA sequences, finding approximately 1 pseudoknot per 40,000 nucleotides. This theoretical probability density compares favorably to what we infer from structure databases and has implications for genome organization, RNA folding algorithms, and the RNA World.
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