1 1 2 Chronic Overeating Impairs Hepatic Glucose Uptake and Disposition 3 4 5
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چکیده
1 2 Chronic Overeating Impairs Hepatic Glucose Uptake and Disposition 3 4 5 Katie C. Coate, Guillaume Kraft, Masakazu Shiota, 1 Marta S. Smith, Ben Farmer, 1 6 Doss W. Neal, 1,2 Phil Williams, Alan D. Cherrington, and Mary Courtney Moore 7 8 Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 9 Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, TN 37232 10 Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232 11 12 Running head: Overeating and liver glucose metabolism 13 14 Grant support 15 Supported by NIH R01-DK-18243 (to A.D.C.), as well as the Metabolic Physiology Shared Resource, Hormone Assay 16 and Analytical Services, and Lipid Cores, supported by NIH grants AM20593 and DK59636. 17 18 Correspondence: 19 Mary Courtney Moore, PhD 20 Dept of Molecular Physiology & Biophysics 21 702 Light Hall 22 Vanderbilt University School of Medicine 23 Nashville, TN 37232-0615 24 Telephone: 615-343-0579 25 FAX: 615-343-0490 26 [email protected] 27 28 Articles in PresS. Am J Physiol Endocrinol Metab (March 17, 2015). doi:10.1152/ajpendo.00069.2015
منابع مشابه
Chronic overeating impairs hepatic glucose uptake and disposition.
Dogs consuming a hypercaloric high-fat and -fructose diet (52 and 17% of total energy, respectively) or a diet high in either fructose or fat for 4 wk exhibited blunted net hepatic glucose uptake (NHGU) and glycogen deposition in response to hyperinsulinemia, hyperglycemia, and portal glucose delivery. The effect of a hypercaloric diet containing neither fructose nor excessive fat has not been ...
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