A New Member of the IkB Protein Family, IkBε, Inhibits RelA (p65)-Mediated NF-kB Transcription
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The NF-kB Regulator Bcl-3 Governs Dendritic Cell Antigen Presentation Functions in Adaptive Immunity
Bcl-3 is an atypical member of the IkB family and modulates gene expression via interaction with p50/NF-kB1 or p52/NF-kB2 homodimers. We report in the present study that Bcl-3 is required in dendritic cells (DCs) to assure effective priming of CD4 and CD8 T cells. Lack of Bcl-3 in bone marrow–derived DCs blunted their ability to expand and promote effector functions of T cells upon Ag/adjuvant ...
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