Molecular genetics of the human glucokinase regulator-fructokinase (GCKR-KHK) region of chromosome 2p23.
نویسندگان
چکیده
19 Veiga-da-Cunha, M., Courtois, S., Michel, A., Gosselain, E. and Van Schaftingen, E. (1996) J. Biol. Chem. 271,6292-6297 20 Charles, R. St., Harrison, R. W., Bell, G. I., Pilkis, S. J. and Weber, I. T. (1994) Diabetes 43, 784-791 21 Bennett, W. S. and Steitz, T. A. (1978) Proc. Natl. Acad. Sci. U.S.A. 75,4848-4852 22 Gidh-Jain, M., Takeda, J., Xu, L. Z., Lange, A. J., Vionnet, N., Stoffel, M., Froguel, P., Velho, G., Sun, F., Cohen, D. et al. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 1932-1936
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Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations
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BACKGROUND Glucokinase (GCK) plays an important role in the regulation of carbohydrate metabolism. In the liver, phosphorylation of glucose to glucose-6-phosphate by GCK is the first step for both glycolysis and glycogen synthesis. However, some vertebrate species are deficient in GCK activity in the liver, despite containing GCK genes that appear to be compatible with function in their genomes...
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 25 1 شماره
صفحات -
تاریخ انتشار 1997