Efficient Integrative Multi-SNP QTL Mapping using Deterministic Approximation of Posteriors
نویسندگان
چکیده
With the increasing availability of functional genomic data (Consortium et al., 2012, Kundaje et al., 2015, Ardlie et al., 2015), incorporating genomic annotations into QTL mapping has become a standard analytical procedure. However, the existing analysis methods often lack rigor and/or computational efficiency. We present a novel algorithm to perform integrative multi-SNP QTL mapping in a probabilistic hierarchical model framework that enables accurate and efficient joint enrichment analysis and the identification of multiple causal variants.
منابع مشابه
Efficient Integrative Multi-SNP Association Analysis via Deterministic Approximation of Posteriors.
With the increasing availability of functional genomic data, incorporating genomic annotations into genetic association analysis has become a standard procedure. However, the existing methods often lack rigor and/or computational efficiency and consequently do not maximize the utility of functional annotations. In this paper, we propose a rigorous inference procedure to perform integrative asso...
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