Nanostructured Lipid Drug Carriers
نویسنده
چکیده
solid lipid carriers – NLC. Particulate lipid matrices in the form of lipid pellets are known from the textbooks since many years, products are on the market (e. g. Mucosolvan retard, Boehringer-Ingelheim). After these lipid pellets as the first generation, P. Speiser developed so-called “lipid nanopellets for oral administration” in the middle of the eighties [1]. This system was not further developed, in many countries no patent protection exists anymore because the fees were not paid.
منابع مشابه
Nanostructured lipid carriers loaded with Melaleuca alternifolia Oil preparation, physicochemical assessment, and evaluation of antimicrobial effects against Staphylococcus epidermidis
Thanks to their outstanding advantages, nanostructured lipid carriers (NLCs) have recognized in various fields these days. One way to discover extra useful products against typical bacteria (e.g., Staphylococcus epidermidis) is NLCs loaded with essential oils. This paper aims to provide NLCs to encapsulate MA oil and characterize and survey the obtained MA...
متن کاملNanostructured lipid carriers: Promising drug delivery systems for future clinics.
During the past decade, the number of studies describing nanostructured lipid carriers (NLCs)-based formulations has been dramatically increased. The raise in NLC exploitation is essentially due to defeated barriers within the technological process of lipid-based nanoparticles' formulation and increased knowledge of the underlying mechanisms of transport of NLCs via different routes of administ...
متن کاملStorage Stability of Wheat Germ Oil Encapsulated within Nanostructured Lipid Carriers
The present study aimed to evaluate the effect of surfactant composition on the physical properties of nanostructured lipid carriers (NLCs) containing wheat germ oil (WGO) and to investigate the influence of both surfactant composition and pH on the oxidative stability of WGO encapsulated within the NLCs. The results showed that the smallest particle size (52.7 nm) was related to the NLC with t...
متن کاملIn vitro characterization and in vivo evaluation of nanostructured lipid curcumin carriers for intragastric administration
BACKGROUND Curcumin has a variety of pharmacological effects. However, poor water solubility and low oral bioavailability limit its clinical utility. A delivery system for nanostructured lipid carriers has been reported to be a promising approach to enhancing the oral absorption of curcumin. The aim of the present study was to investigate the pharmacokinetics, tissue distribution, and relative ...
متن کاملAerosol delivery of ferulic acid-loaded nanostructured lipid carriers: A promising treatment approach against the respiratory disorders
Introduction: Treatment of lung diseases is one of the major healthcare challenges. Ferulic acid (FA), a phenolic compound with well-established antioxidant and anti-inflammatory properties, has shown promising therapeutic potential against the pulmonary disorders; however, low bioavailability may negatively affect its efficiency. This, prompted us to incorporate FA into the nanostructured ...
متن کاملMoisturizing effects of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) using deionized and magnetized water by in vivo and in vitro methods
Objective(s): The present study aimed to determine and compare moisturizing and occlusion effects of different solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) using magnetized water and deionized water.Materials and Methods: SLN formulations were prepared using various lipids, including Tripalmitin, Compritol®, Pr...
متن کامل