Dengue infection: a growing global health threat.

New approaches to structure-based discovery of dengue protease inhibitors.

Dengue virus (DENV), a member of the family Flaviviridae, presents a tremendous threat to global health since an estimated 2.5 billion people worldwide are at risk for epidemic transmission. DENV infections are primarily restricted to sub-tropical and tropical regions; however, there is concern that the virus will spread into new regions including the United States. There are no approved antivi...

Current epidemiology and clinical practice in arboviral infections – implications on blood supply in South-East Asia

Arthropod-borne viruses (arboviruses) are a growing threat to global health. Complex vector-virus-host interactions lead to unpredictable epidemiological patterns. Difficulties in accurate surveillance including imperfect diagnostic tools impair effective response to outbreaks. With arboviral infections causing a wide spectrum of disease severity, from asymptomatic infection to fatal neuroinvas...

Dengue: Global Threat.

Dengue is a mosquito-borne viral disease, which is currently an expanding global problem. Four closely related dengue serotypes cause the disease, which ranges from asymptomatic infection to undifferentiated fever, dengue fever (DF), and dengue hemorrhagic fever (DHF). DHF is characterized by fever, bleeding diathesis, and a tendency to develop a potentially fatal shock syndrome. Dengue infecti...

Dengue: global health threat.

Solving the Mystery of Dengue in Iran; Are We Close to an Answer?

Dengue fever is a mosquito-borne infection which is endemic in Southeast Asia. Although it has not been distributed in Iran, locating near other countries where the Dengue has been revealed is a threat for Iran because different connection between countries may increase the rate of infection.