In vitro and in vivo gene therapy vector evolution via multispecies 3 interbreeding and re - targeting of adeno - associated viruses
نویسندگان
چکیده
5 6 Dirk Grimm, Joyce S. Lee, Lora Wang, Tushar Desai, Bassel Akache, Theresa A. 7 Storm, and Mark A. Kay 8 9 10 Stanford University, School of Medicine, Departments of Pediatrics and Genetics, 300 11 Pasteur Drive, Department of Biochemistry, 279 Campus Drive, Stanford, California, 12 94305, USA 13 #Current address: University of Heidelberg, Cluster of Excellence CellNetworks, 14 BIOQUANT, Im Neuenheimer Feld 267, D-69120 Heidelberg, Germany 15 16 *Correspondence should be addressed to M.A.K.; e-mail : [email protected] 17 Phone 650-498-6531 18 Fax 650-498-6540 19 20 21 Running title: AAV vector evolution via interbreeding and re-targeting 22 Word count: Abstract: 252 Text: 15557 23 AC CE PT ED Copyright © 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Virol. doi:10.1128/JVI.00254-08 JVI Accepts, published online ahead of print on 9 April 2008
منابع مشابه
In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses.
Adeno-associated virus (AAV) serotypes differ broadly in transduction efficacies and tissue tropisms and thus hold enormous potential as vectors for human gene therapy. In reality, however, their use in patients is restricted by prevalent anti-AAV immunity or by their inadequate performance in specific targets, exemplified by the AAV type 2 (AAV-2) prototype in the liver. Here, we attempted to ...
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