associated with reduced 1 pathogenicity in Lujo virus - infected cynomolgus macaques 2 3 Running title : Gene expression in Lujo and Lassa - infected macaques 4 5 Angela
نویسندگان
چکیده
Delayed inflammatory and cell death responses are associated with reduced 1 pathogenicity in Lujo virus-infected cynomolgus macaques 2 3 Running title: Gene expression in Lujo and Lassa-infected macaques 4 5 Angela L. Rasmussen, Nicolas Tchitchek, David Safronetz, Victoria S. Carter, 6 Christopher M. Williams, Elaine Haddock, Marcus J. Korth, Heinz Feldmann, and 7 Michael G. Katze 3** 8 9 Department of Microbiology, University of Washington, Seattle, WA 10 Laboratory of Virology, Division of Intramural Research, National Institute of Allergy 11 and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, 12 Hamilton, MT 13 Washington National Primate Research Center, Seattle, WA 14 15 16 *These authors contributed equally to this publication 17 **Corresponding author: Michael G. Katze, University of Washington School of 18 Medicine, Department of Microbiology, Box 358070, E-mail: [email protected] Telephone: 19 (206) 732-6136, Fax: (206) 732-6056 20 21 22 23 JVI Accepts, published online ahead of print on 17 December 2014 J. Virol. doi:10.1128/JVI.02246-14 Copyright © 2014, American Society for Microbiology. All Rights Reserved.
منابع مشابه
Delayed inflammatory and cell death responses are associated with reduced pathogenicity in Lujo virus-infected cynomolgus macaques.
UNLABELLED To identify host factors associated with arenavirus virulence, we used a cynomolgus macaque model to evaluate the pathogenesis of Lujo virus (LUJV), a recently emerged arenavirus that caused an outbreak of severe viral hemorrhagic fever in southern Africa. In contrast to human cases, LUJV caused mild, nonlethal illness in macaques. We then compared this to contrasting clinical outcom...
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