A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease.
نویسندگان
چکیده
There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer's disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD plus.
منابع مشابه
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Subjective Cognitive Decline (SCD) refers to a self-experienced persistent decline in cognitive abilities in comparison with a prior normal status and independent of the objective performance on neuropsychological tests (Jessen et al., 2014). It has been proposed that SCDmight appear at the end of the preclinical phase of Alzheimer’s Disease (AD) even in the absence of significant objective imp...
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ورودعنوان ژورنال:
- Alzheimer's & dementia : the journal of the Alzheimer's Association
دوره 10 6 شماره
صفحات -
تاریخ انتشار 2014