New insights into the bacterial RNA polymerase inhibitor CBR 703 1 as a starting point for optimization as an anti - infective agent
نویسندگان
چکیده
1 Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Department of Drug Design 5 and Optimization and 2 Pharmaceutical and Medicinal Chemistry, Saarland University, Campus 6 C2.3, D-66123 Saarbrücken, Germany. 3 Helmholtz Centre for Infection Research, 7 Inhoffenstraße 7, 38124 Braunschweig, Germany. 8 * Corresponding author. Fax: (+49) 681 302 70308 E-mail: [email protected] 9 10 11
منابع مشابه
New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent.
CBR703 was reported to inhibit bacterial RNA polymerase (RNAP) and biofilm formation, considering it to be a good candidate for further optimization. While synthesized derivatives of CBR703 did not result in more-active RNAP inhibitors, we observed promising antibacterial activities. These again correlated with a significant cytotoxicity toward mammalian cells. Furthermore, we suspect the promi...
متن کاملNew insights into the bacterial RNA polymerase inhibitor CBR 703 as a 2 starting point for optimization as an anti - infective agent
Weixing Zhu, Jörg Haupenthal, Matthias Groh, Michelle Fountain and Rolf W. 4 Hartmann* b] 5 [a] Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Department of Drug Design 6 and Optimization and [b] Pharmaceutical and Medicinal Chemistry, Saarland University, Campus 7 C2_3, D-66123 Saarbrücken, Germany. [c] Helmholtz Centre for Infection Research, 8 Inhoffenstraße 7, Braunschweig...
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