Biochemical Characterization of Lycopene Extracted from Citrullus Lanatus and its Therapeutic Potential to Dalton’s Lymphoma Ascites Tumor Model

Background and purpose: Cancer is a major public health burden in both developed and developing countries. Natural and some synthetic compounds can prevent, suppress, or reverse the progression of cancer. The main purpose of the work is to provide cheapest plant based therapy for treatment of cancer, in order to reduce the risk of cancer. Material and Methods: Bioactive compound namely lycopene was extracted from Citrullus lanatus fruit and its purity was analyzed by HPLC. The tumor induced swiss albino mice was treated with lycopene and comparative studies was carried out with standard available carboplatin. Experimental samples/tissues of the mice were subjected to various experiments to find out efficacy of lycopene action against Dalton’s lymphoma ascites tumor. Impact of lycopene in cancer expressed in terms of suppression in cell arrest/control measures were confirmed by western blot techniques Result: Lycopene combined carboplatin showed promising cytotoxic activity against Dalton’s lymphoma ascites tumor when compared to carboplatin. The experimental research showed better healing or suppression of cancer proliferation. Conclusion: Experiment was designed in the form of cancer induction in mice model, different batches of experimental animals were treated and results concluded that combination of carboplatin with lycopene showed better therapeutic effect on Dalton’s lymphoma ascites tumor. In future lycopene will be formulated as pharmaceutical product.