Emetine hydrochloride and chloroquine in the treatment of children with amoebic liver abscess.

نویسندگان

  • J N Scragg
  • S J Powell
چکیده

Although amoebic liver abscess is infrequent in children, the outcome is much less favourable than it is in adults. When treated with combined emetine hydrochloride, chloroquine, and aspiration, the prognosis is excellent in adults (Wilmot, 1962), this regime being more successful than treatment with a single drug (Wilmot, Powell, and Adams, 1959; Wilmot, Powell, MacLeod, and Elsdon-Dew, 1964). In children our current therapy is similar to that employed successfully in adults, but our mortality has been over 50% (Scragg, 1960). In this short paper we compare the results of treatment in two groups of children with amoebic liver abscess, the one group treated with emetine hydrochloride and the other with chloroquine. This trial was designed to determine whether the high mortality in children might be due to the toxic effect of emetine, particularly on the myocardium.

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منابع مشابه

Children with Amoebic Liver Abscess

A combination of emetine hydrochloride with chloroquine yields better results than either drug alone in the treatment of amoebic liver abscess in adults (Wilmot, Powell, and Adams, 1959). A similar combination of dehydroemetine with chloroquine is equally satisfactory (Wilmot, Powell, MacLeod, and Elsdon-Dew, 1964; Powell, Wilmot, MacLeod, and Elsdon-Dew, 1967). Dehydroemetine is claimed to be ...

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عنوان ژورنال:
  • Archives of disease in childhood

دوره 41 219  شماره 

صفحات  -

تاریخ انتشار 1966