Mode of action of a new isoxazoline compound
نویسندگان
چکیده
A new isoxazoline compound (5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3(3-methylthiophen-2-yl)-1,2-isoxazoline; code name, EK-5229) was reported to have safety in rice and control barnyardgrass (Echinochloa crus-galli), but its mode of action was unknown. The compound did not inhibit germination of sensitive grasses, but it inhibited further growth. The symptom was primarily stunting and discoloration, but did not resemble those of existing herbicides. In whole plant studies, EK-5229 completely inhibited root elongation of corn, susceptible grass, at 1μM within 6 h of application. EK-5229 inhibited incorporation of [C]glucose into hemicellulose and cellulose of corn root cell walls by 50 to 70% at 1μM after 24 h. The effect of EK-5229 on cell wall biosynthesis was dose-dependent in the range between 0.01 and 1μM, and corresponded with the dose-dependency of growth of corn root. However, in terms of time-course response, inhibition of [C]glucose incorporation into the cell wall constituents was evident after 12 h of treatment, which was after the growth inhibition occurred. This result suggested that the mechanism of action of EK-5229 might be directly or indirectly associated with cell wall biosynthesis in susceptible plants.
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