Regucalcin, a novel factor implicated in hyperlipidemia
نویسنده
چکیده
Regucalcin, which was discovered as a calcium-binding protein in 1978, has been demonstrated to play a multifunctional role as a suppressor in signaling transduction in various types of cells and tissues. Regucalcin has been shown to regulate intracellular calcium homeostasis, protein kinases and phosphatases, nitro oxide production, protein synthesis, gene expression, cell proliferation and apoptotic cell death. Regucalcin overexpression and deficiency induces the disorders of bone metabolism, lipid production and glucose metabolism in vivo, indicating an involvement in metabolic disorder. Regucalcin overexpression induces hyperlipidemia implicated in the adipose and liver, and its deficiency caused lipid accumulation in the liver. Regucalcin overexpression stimulates glucose transport and lipid production in liver cells. In addition, regucalcin was found to mediate insulin resistance. Regucalcin regulates the gene expression of insulin receptor and PI3 kinase in liver cells. This review will discuss an involvement of regucalcin in metabolic disorder implicated in lipid metabolism and diabetes.
منابع مشابه
Change in lipid components in the adipose and liver tissues of regucalcin transgenic rats with increasing age: suppression of leptin and adiponectin gene expression.
Regucalcin plays a multifunctional role as a regulatory protein in intracellular signaling pathway in many cell types. Regucalcin transgenic (TG) rats have been shown to experience hyperlipidemia with increasing age. This study was undertaken to determine whether lipid components in the adipose and liver tissues are changed in regucalcin TG rats in vivo. Female regucalcin TG rats were used at 7...
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