Corneal Nerves in Refractive Surgery and Dry Eye
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چکیده
منابع مشابه
Postrefractive surgery dry eye.
PURPOSE OF REVIEW To report the recently published literature on ocular surface changes after refractive surgery, as well as the outcomes of treatment modalities on postrefractive surgery dry eye. RECENT FINDINGS Cyclosporine, the first US Food and Drug Administration approved agent to treat the underlying pathological mechanism of chronic dry eye, has demonstrated promising results in dry ey...
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Alterations in corneal innervations result in impaired corneal sensation, severe dry eye and damage to the epithelium that may in turn lead to corneal ulcers, melting and perforation. These alterations can occur after refractive surgery. We have discovered that pigment epithelium-derived factor (PEDF) plus docosahexaenoic acid (DHA or the docosanoid bioactive neuroprotectin D1 (NPD1)) induces n...
متن کاملNeural basis of sensation in intact and injured corneas.
A renewed interest in the characteristics and neural basis of corneal and conjunctival sensations is developing in recent years due to the high incidence of discomfort and altered sensitivity of the cornea following refractive surgery, use of contact lenses and dry eyes. Corneal nerves are functionally heterogeneous: about 20% respond exclusively to noxious mechanical forces (mechano-nociceptor...
متن کاملChronic dry eye symptoms after LASIK: parallels and lessons to be learned from other persistent post-operative pain disorders
Laser in-situ keratomileusis (LASIK) is a commonly performed surgical procedure used to correct refractive error. LASIK surgery involves cutting a corneal flap and ablating the stroma underneath, with known damage to corneal nerves. Despite this, the epidemiology of persistent pain and other long-term outcomes after LASIK surgery are not well understood. Available data suggest that approximatel...
متن کاملDry eye disease after refractive surgery: comparative outcomes of small incision lenticule extraction versus LASIK.
PURPOSE To compare small incision lenticule extraction (SMILE) versus LASIK for post-refractive dry eye disease. DESIGN Prospective, comparative, nonrandomized clinical study. PARTICIPANTS Thirty patients scheduled for bilateral myopic SMILE and 30 age-, sex-, and refraction-matched patients scheduled for bilateral myopic LASIK were enrolled and followed for 6 months after the surgery. ME...
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