Gold nanoparticle-based sensing strategies for biomolecular detection*
نویسندگان
چکیده
Gold nanoparticles (AuNPs) have been extensively employed in biological studies for several decades. More recently, progress has well demonstrated that DNA-conjugated AuNPs are highly promising nanoprobes for the sensitive detection of various biomolecules, based on the unique optical and electronic properties of AuNPs. In this short review, we focus on the use of AuNP-based nanoprobes for biological detection of nucleic acids, proteins, and other biologically relevant small-molecule targets, mainly based on the recent progress in our laboratory.
منابع مشابه
Size-optimized galactose-capped gold nanoparticles for the colorimetric detection of heat-labile enterotoxin at nanomolar concentrations.
The development of a galactose-capped gold nanoparticle-based colorimetric sensor for the detection of the lectin heat-labile enterotoxin is reported. Heat-labile enterotoxin is one of the pathogenic agents responsible for the intestinal disease called 'traveller's diarrhoea'. By means of specific interaction between galactose moieties attached to the surface of gold nanoparticles and receptors...
متن کاملUse of laser-triggered gold nanoparticle-grafted dual light and temperature-responsive polymeric sensor for the recognition of thioguanine as anti-tumor agent
Objective(s): Today, there is an urgent need for improved sensor materials for drug sensing and effective monitoring and interventions in this area are highly required to struggle drug abuse. The present study aimed to synthesize a thioguanine-responsive sensor based on a nanocomposite consisting of AuNP-grafted light- and temperature-responsive poly butylmethacrylate-co-acrylamide-co-methacryl...
متن کاملCytotoxity Assessment of Gold Nanoparticle-Chitosan Hydrogel Nanocomposite as an Efficient Support for Cell Immobilization: toward Sensing Application
Cell-based biosensors have become a research hotspot in biosensors and bioelectronics fields. The main feature of cell-based biosensors is the immobilization of living cell on the surface of transducers. Different types of polymers which are used as scaffolds for cell growth should be biocompatible and have reactive functional groups for further attachment of biomolecules. In this work, the cel...
متن کاملThe use of gold nanoparticle aggregation for DNA computing and logic-based biomolecular detection.
The use of DNA molecules as a physical computational material has attracted much interest, especially in the area of DNA computing. DNAs are also useful for logical control and analysis of biological systems if efficient visualization methods are available. Here we present a quick and simple visualization technique that displays the results of the DNA computing process based on a colorimetric c...
متن کاملHydrogen sensing by localized surface plasmon resonance in colloidal solutions of Au-WO3-Pd
Nowadays, hydrogen has attracted significant attention as a next generation clean energy source. Hydrogen is highly flammable, so detection of hydrogen gas is required. Gold nanoparticle based localized surface plasmon resonance (LSPR) is an advanced and powerful sensing technique, which is well known for its high sensitivity to surrounding refractive index change in the local environment. We p...
متن کامل