Madin-Darby canine kidney cells display type I and type II insulin-like growth factor (IGF) receptors.

نویسندگان

  • N L Krett
  • J H Heaton
  • T D Gelehrter
چکیده

Using affinity cross-linking techniques, we report the presence of type I IGF and type II IGF receptors in Madin-Darby canine kidney cells, a line of cells lacking insulin receptors. The IGF receptors were further characterized by competition binding studies and found to be similar to IGF receptors in other tissue types. In Madin-Darby canine kidney cells, the type I IGF receptor binds IGF-I greater than IGF-II greater than insulin and the type II IGF receptor binds IGF-II and IGF-I with approximately the same affinity, but does not bind insulin.

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عنوان ژورنال:
  • Biochemical and biophysical research communications

دوره 134 1  شماره 

صفحات  -

تاریخ انتشار 1986