Aqueous Humor Outflow Resistance
نویسندگان
چکیده
This chapter was originally published in the book Current Topics in Membranes, Vol. 62, published by Elsevier, and the attached copy is provided by Elsevier for the author's benefit and for the benefit of the author's institution, for non-commercial research and educational use including without limitation use in instruction at your institution, sending it to specific colleagues who know you, and providing a copy to your institution’s administrator.
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The flow of aqueous humor through micro-porous filters.
Flow resistance was measured as bovine and primate aqueous humor was passed through Nuclepore polycarbonate filters having flow dimensions similar to those found within the juxtacanalicular meshwork of the aqueous outflow network. The results indicate that aqueous humor has a greater flow resistance than isotonic saline; this greater resistance is attributable to proteins or glycoproteins in aq...
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Glaucoma is a family of optic neuropathies which cause irreversible but potentially preventable vision loss. Vision loss in most forms of glaucoma is related to elevated IOP with subsequent injury to the optic nerve. Secretion of aqueous humor and regulation of its outflow are physiologically important processes for maintaining IOP in the normal range. Thus, understanding the complex mechanisms...
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Aqueous humor outflow resistance was studied in monkeys (Cercopithecus ethiops) with intact oculomotor nerves, after the nerve had been severed on one side, and during electrical stimulation of the severed nerve. Pupil diameters (on both eyes) and outflow resistance on the non-stimulated side acted as controls. It was found that the outflow resistance increased and the pupil dilated when the ne...
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Fluid flow in the anterior chamber maintains intraocular pressure (IOP) and globe shape and supplies oxygen and nutrients to the nonvascularized cornea, lens, and trabecular meshwork (TM). Glaucoma is a progressive optic neuropathy often caused by elevated IOP consequent to abnormally high resistance to aqueous humor drainage via the TM and Schlemm’s canal. Compounds with cytoskeletal effects o...
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The juxtacanalicular connective tissue (JCT) is widely believed to generate the bulk of aqueous humor outflow resistance, while the pores of the inner wall endothelium are thought to generate at most 10% of this resistance in humans. However, the hydrodynamic interaction of these two components of the aqueous outflow system, which arises because of their spatial proximity, has only recently bee...
متن کاملPerfusion of his-tagged eukaryotic myocilin increases outflow resistance in human anterior segments in the presence of aqueous humor.
PURPOSE A previous study by the authors has shown that recombinant myocilin purified from a prokaryotic expression system increases outflow resistance in cultured human anterior segments. The present study was performed to determine whether full-length myocilin purified from a human trabecular meshwork cell expression system alters outflow resistance after infusion into human anterior segments....
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