Modulation of ECG Alterations and Cardiac Hypertrophy by Fenofibrate in Isoproterenol Induced Heart Failure

The present study was designed to evaluate the cardioprotective effect of fenofibrate against isoproterenol (ISO) induced heart failure (HF) in rats by studying cardiac injury markers, left ventricular hypertrophy and electrocardiographic changes. Rat model of HF was induced by ISO administration (85 mg/kg, s.c.) at an interval of 24h on 0 and 1st day. Fifteen days post ISO injection, rats showed significant abnormalities in ECG profile along with increased serum levels of cardiac injury markers (creatine kinase-MB) and left ventricular hypertrophy. Treatment with fenofibrate (100mg/kg, orally) significantly improved ISO-induced ECG alterations, cardiac injury and left ventricular hypertrophy. In conclusion our results suggest that fenofibrate has ability to provide effective protection against electrical and structural changes developed in the heart of rat model of ISO-induced HF.