Influence of dipeptidyl peptidase IV on enzymatic properties of adenosine deaminase.

Competitive Antagonists of Adenosine Deaminase versus Enzymatic Inhibitors: Complementary Approaches Targeting Dipeptidyl Peptidase 4 (DP IV) and their Relation to MERS-CoV Infection

Cite this article: Reinhold D, Kähne T, Brocke S (2016) Competitive Antagonists of Adenosine Deaminase versus Enzymatic Inhibitors: Complementary Approaches Targeting Dipeptidyl Peptidase 4 (DP IV) and their Relation to MERS-CoV Infection. Ann Clin Cytol Pathol 2(3): 1028. *Corresponding author Stefan Brocke, Department of Immunology, University of Connecticut Health Center, Farmington, CT 0603...

Activity of Dipeptidyl Peptidase-IV/CD26 and Aminopeptidase N/CD13 in Secretome of Mesenchymal Stem Cells after Treatment with LPS and PMA

Background: Emerging evidence suggests that secretome of mesenchymal stem cells has many anti-inflammatory and regenerative properties, which makes it a suitable candidate for the treatment of autoimmune and degenerative diseases. Dipeptidyl Peptidase-IV (DPP-IV)/CD26 and Aminopeptidase N (APN)/CD13 are ubiquitous ecto-enzymes which can digest various substrates including some ...

Dipeptidyl peptidase IV and adenosine deaminase activity. Decrease in depression.

Dipeptidyl peptidase IV (DPPIV) and adenosine deaminase (ADA), two T cell associated enzymes, are known to have a possible interaction and play essential roles in immune system functioning. On the other hand, depression has been shown to be accompanied with some immune-inflammatory alterations. In this regard, in order to make a contribution to the understanding of the ongoing immune disturbanc...

Endothelial Catabolism of Extracellular Adenosine during Hypoxia: Role of Surface Adenosine Deaminase and CD26 Inaugural-Dissertation zur Erlangung des Doktorgrades

The Binding Site of Human Adenosine Deaminase for Cd26/Dipeptidyl Peptidase IV

Human, but not murine, adenosine deaminase (ADA) forms a complex with the cell membrane protein CD26/dipeptidyl peptidase IV. CD26-bound ADA has been postulated to regulate extracellular adenosine levels and to modulate the costimulatory function of CD26 on T lymphocytes. Absence of ADA-CD26 binding has been implicated in causing severe combined immunodeficiency due to ADA deficiency. Using hum...