Peroxisome inheritance and differentiation
ثبت نشده
چکیده
490 3 FEBRUARY 2017 • VOL 355 ISSUE 6324 sciencemag.org SCIENCE economic performance to polling data. Elections were about 80 to 90% predictable, despite uncertainties with available data. Polling data were very important to successful prediction, although it was necessary to correct for systematic biases. Unexpectedly, economic indicators were only weakly predictive. As data sources improve and grow, predictive power is expected to increase. —BJ
منابع مشابه
Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts
Myogenesis is a crucial process governing skeletal muscle development and homeostasis. Differentiation of primitive myoblasts into mature myotubes requires a metabolic switch to support the increased energetic demand of contractile muscle. Skeletal myoblasts specifically shift from a highly glycolytic state to relying predominantly on oxidative phosphorylation (OXPHOS) upon differentiation. We ...
متن کاملPex3 peroxisome biogenesis proteins function in peroxisome inheritance as class V myosin receptors
In Saccharomyces cerevisiae, peroxisomal inheritance from mother cell to bud is conducted by the class V myosin motor, Myo2p. However, homologues of S. cerevisiae Myo2p peroxisomal receptor, Inp2p, are not readily identifiable outside the Saccharomycetaceae family. Here, we demonstrate an unexpected role for Pex3 proteins in peroxisome inheritance. Both Pex3p and Pex3Bp are peroxisomal integral...
متن کاملA conserved function for Inp2 in peroxisome inheritance.
In budding yeast Saccharomyces cerevisiae, the peroxisomal protein Inp2 is required for inheritance of peroxisomes to the bud, by connecting the organelles to the motor protein Myo2 and the actin cytoskeleton. Recent data suggested that the function of Inp2 may not be conserved in other yeast species. Using in silico analyses we have identified a weakly conserved Inp2-related protein in 18 spec...
متن کاملPex19p contributes to peroxisome inheritance in the association of peroxisomes to Myo2p.
During budding of yeast cells peroxisomes are distributed over mother cell and bud, a process that involves the myosin motor protein Myo2p and the peroxisomal membrane protein Inp2p. Here, we show that Pex19p, a peroxin implicated in targeting and complex formation of peroxisomal membrane proteins, also plays a role in peroxisome partitioning. Binding studies revealed that Pex19p interacts with...
متن کاملInp1p is a peroxisomal membrane protein required for peroxisome inheritance in Saccharomyces cerevisiae
Cells have evolved molecular mechanisms for the efficient transmission of organelles during cell division. Little is known about how peroxisomes are inherited. Inp1p is a peripheral membrane protein of peroxisomes of Saccharomyces cerevisiae that affects both the morphology of peroxisomes and their partitioning during cell division. In vivo 4-dimensional video microscopy showed an inability of ...
متن کامل