Vasopressin stimulates phospholipase D, protein synthesis and RNA accretion in L6 myoblasts.

A cyclo-oxygenase metabolite of arachidonic acid, prostaglandin F, appears to be closely involved in the stimulation of protein synthesis by insulin in skeletal muscle [l] and in L6 myoblasts [2]. At present, however, it is not clear if the cyclo-oxygenase pathway is the only route leading to increased protein synthesis in skeletal muscle. In 3T3 fibroblasts, exogenous diacylglycerol has been shown to stimulate protein synthesis [3] and recently it has been suggested that in rat myocytes, the stimulation of protein synthesis by the endothelins is linked to inositol lipid hydrolysis