Liver Transplantation - What the Physician Should Know?

نویسندگان

  • Amit Gupte
  • Akash Shukla
چکیده

T f i r s t success fu l human liver transplantation (LT) in the world was reported by Sir Thomas Starzl in 1967. 1 In the following years, the results of liver transplantation were poor. Complex surgical procedure and nonselective immunosuppression made patients highly vulnerable to infections and the physicians had a daunting task of balancing this with the risk of rejection. With introduction of cyclosporine in 1979 by Calne2 and tacrolimus in 1990 byStarzl3,outcomes steadily improved. Calcineurin inhibitors have remained the backbone of immunosuppressive regimens after liver transplantation. Improvement in surgical techniques, intensive care and immunosuppress ive medica t ions resul ted in l iver transplantation getting accepted as standard of care for end stage liver disease in 1983 in USA. The Human Organs Transplantation Act was passed in India in 1994 and first successful liver transplantation in India was reported in 1998.4 In western countries, majority of l iver transplants are from a deceased donor (DDLT) while on the other hand liver transplants from living donors (LDLT) have expanded in Asian countries. In India transplant programs in north India do predominantly LDLT and those in south and west do a combination of DDLT and LDLT.5

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عنوان ژورنال:
  • The Journal of the Association of Physicians of India

دوره 64 12  شماره 

صفحات  -

تاریخ انتشار 2016