cGAMP: A tale of two signals.
نویسندگان
چکیده
In this issue of JEM, Swanson et al. (https://doi.org/10.1084/jem.20171749) report an unanticipated role for cGAMP in priming and activation of inflammasomes in addition to its well-characterized function as an endogenous second messenger inducing type I interferons in the cytosolic DNA-sensing pathway.
منابع مشابه
cGAMP: A tale of two signals
DNA, when inadvertently present in the cytosol, acts as a danger signal alarming the host of infection or cellular damage and triggers a potent innate immune response characterized by the induction of type I IFNs and proinflammatory cytokines. The two major DNA sensors mediating these responses are the cyclic GMP-AMP synthase (cGAS) and the inflammasome forming receptor absent in melanoma 2 (AI...
متن کاملcGAMP: A tale of two signals
DNA, when inadvertently present in the cytosol, acts as a danger signal alarming the host of infection or cellular damage and triggers a potent innate immune response characterized by the induction of type I IFNs and proinflammatory cytokines. The two major DNA sensors mediating these responses are the cyclic GMP-AMP synthase (cGAS) and the inflammasome forming receptor absent in melanoma 2 (AI...
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Cyclic GMP-AMP (cGAMP) synthase (cGAS) is recently identified as a cytosolic DNA sensor and generates a non-canonical cGAMP that contains G(2',5')pA and A(3',5')pG phosphodiester linkages. cGAMP activates STING which triggers innate immune responses in mammals. However, the evolutionary functions and origins of cGAS and STING remain largely elusive. Here, we carried out comprehensive evolutiona...
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ورودعنوان ژورنال:
- The Journal of experimental medicine
دوره 214 12 شماره
صفحات -
تاریخ انتشار 2017