Enantioselective approach to functionalized quinolizidines: synthesis of (+)-julandine and (+)-cryptopleurine.
نویسندگان
چکیده
An efficient synthesis of functionalized quinolizidines was developed from an enantiomerically enriched γ-nitroketone, which is easily prepared by an organocatalytic ketone-nitroalkene Michael addition. Oxidative ring expansion of the nitroketone followed by reductive ring-opening leads to a suitably functionalized nitrodiol which is an intermediate to the title compounds.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 33 شماره
صفحات -
تاریخ انتشار 2012