Investigation of the defect in a variant of hereditary methemoglobinemia.

By PHILIP L. TOWNES AND MARTIN MomusoN A VARIANT of hereditary methemoglobinemia exhibiting dominant inheritance of normal methemoglobin has recently been reported? Although the TPN and DPN methemoglobin reductases were found to be normal, an inability to utilize glucose for the reduction of methemoglobin was demonstrated. The present report describes further attempts to define more definitely the specific metabolic defect responsible for this type of hereditary methemoglobinemia.