Kininogen (hk) Deficiency Modulates Chronic Intestinal Inflammation in Genetically Susceptible Rats
نویسندگان
چکیده
Irma Isordia-Salas, Robin A. Pixley, Fengling Li , Irma Sainz, R Balfour Sartor, Albert Adam and Robert W. Colman. The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA; Center for Gastrointestinal Biology and Disease, Departments of Medicine, Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, 27599, USA; Department of Pharmacy, University of Montreal, Montreal, Quebec H3C 3J7, Canada.
منابع مشابه
Kininogen deficiency modulates chronic intestinal inflammation in genetically susceptible rats.
Genetically susceptible Lewis rats injected in the intestinal wall with peptidoglycan-polysaccharide (PG-APS) polymers develop chronic granulomatous enterocolitis concomitant with activation of the kallikrein-kinin system. To elucidate the role of high-molecular-weight kininogen (HK) in chronic enterocolitis, we back crossed Brown-Norway rats having a HK deficiency with Lewis rats for five gene...
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BACKGROUND The plasma kallikrein-kinin (K-K) system is activated in acute and chronic relapsing intestinal inflammation induced in Lewis rats by intramural injection of exogenous bacterial components. AIMS To determine whether this effect is model specific, K-K system activation was investigated in a modified indomethacin induced enterocolitis model, as well as bradykinin 2 (B2) receptor dist...
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Crohn disease is immunologically mediated and characterized by intestinal and systemic chronic inflammation. In a rat model, injection of peptidoglycan-polysaccharide complexes into the intestinal wall induced chronic inflammation in Lewis but neither Fischer nor Buffalo rats, indicating a differential genetic susceptibility. Proteolysis of plasma high molecular weight kininogen (HK) yielding b...
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Blood MS #2003-02-0661 The Mutation SN Leads to N-glycosylation and Increases the Cleavage of High Molecular Weight Kininogen In Rats Genetically Susceptible to Inflammation Irma Isordia-Salas, Robin A. Pixley , Hemant Parekh , Satya P. Kunapuli , Fengling Li, Anthony Stadnicki, Yingzhang Lin, R. Balfour Sartor , and Robert W. Colman. The Sol Sherry Thrombosis Research Center and 2 Department o...
متن کاملA point mutation of alanine 163 to threonine is responsible for the defective secretion of high molecular weight kininogen by the liver of brown Norway Katholiek rats.
To clarify the mechanism of the secretion defect of high molecular weight kininogen (HK) and low molecular weight kininogen (LK) by the liver of Brown Norway (B/N) Katholiek rats causing plasma kininogen deficiency, we cloned cDNAs for HK from cDNA libraries of the livers of B/N Katholiek and B/N Kitasato rats. A point mutation of G to A at nucleotide 487 was found in the cDNA of B/N Katholiek ...
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