Platelet Survival Time

average 1 1/2 ± SEM; normal t 1/2 3.7 ± 0.03 days) in 88 out of 128 (69%) men with coronary disease. In 35 out of 47 men with hyperprebetalipoproteinemia, SURV was shortened (3 ± 0.09 days) (74%). Of30 men with hyperbetalipoproteinemia, SURV was shortened (2.5 ± 0.10 days) in 26 (87%). Of 51 men without hyperlipoproteinemia, SURV was normal (3.3 ± 0.10 days) in 24 (47%). Dietary alteration of serum triglyceride was undertaken in 12 men with hyperprebetalipoproteinemia, and in eight a decrease of triglyceride of more than 75 mg% was achieved (324 ± 21-219 ± 18 mg%; P < 0.001) with an increase of SURV (2.2 ± 0.11-2.8 ± 0.13 days; P < 0.001). In four, serum triglyceride increased by more than 75 mg% (279 ± 14-451 ± 28 mg%) and SURV decreased (2.7 ± 0.16-2.3 ± 0.21 days). Cholestyramine (16 g g.d.) and diet decreased serum cholesterol (348 ± 7.6-319 ± 6.3 mg%; P < 0.001) in 15 men with hyperbetalipoproteinemia and SURV increased (2.3 ± 0.08-2.7 ± 0.07 days; P < 0.001). Results suggest that SURV is shortened in men with coronary disease, particularly in those with hyperlipoproteinemia, and that alteration of triglyceride and cholesterol are associated with alteration of SURV.