Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases.

Effect of Purine Nucleoside Analogue-Acyclovir on The Sperm Parameters and Testosterone Production in Rats

P-51: A Purine Nucleoside Analogue_Acyclovir Impairs Testicular Functions in Male Rats

Background: Acyclovir (ACV) is a synthetic purine nucleoside analog drived from guanosine. ACV possesses antiviral activity against Herpes Simplex Virus types 1 and 2 (HSV-1 and HSV-2 ), Varicella Zoster virus (VZV) , Epstein Barr virus (EBV) and Cytomegalovirus (CMV). ACV exert its effects by interfering with DNA synthesis,thus inhibiting viral replication. ACV is khown to be toxic to gonads,t...

Spectrum of neurologic complications in chronic lymphocytic leukemia.

Neurologic disease is believed to be an unusual complication during the course of chronic lymphocytic leukemia. Nevertheless, it has already been proven in autopsy series that the incidence of occult nervous system infiltration is much higher than was previously expected. The advent of more potent drugs to treat this lymphoproliferative disorder has brought a new hope for a possible cure in the...

Study of new NBS-LRR genes analogues in cucurbits native types in Iran

Nucleotide binding site leucine-rich repeats (NBS-LRR) accounting for the main disease resistance proteins play an important role in plant defense against pathogen attack. The current study aimed to identify new NBS-LRR gene members in native types of cucurbit species in Iran. Accordingly, DNAs of melon, cucumber and cantaloupe native types to Iran were identified using three primer pairs. PCR ...

Purine nucleoside analogs: emerging roles in indolent lymphoproliferative disorders.

R ECENTLY, a great deal of interest has been generated in three new purine nucleoside analogs because of their remarkable activity in a variety of incurable malignant lymphoproliferative disorders. 2-Fluoro-ara-AMP (fludarabine), 2-deoxycoformycin (ZDCF, pentostatin), and 2-chlorodeoxyadenosine (2-CdA) are all structurally similar analogs of adenosine, but they differ in their interaction with ...