Chemotherapeutic studies on transplantable mouse tumors.

Transplants of tumors were made in the lower right hind leg, and treatment was begun when the tumor volume was 150-200 mm.3 For lymphosarcoma, this was 12 to 16 days; for mammary carcinoma A ? 179955, 10 to 15 days; for mammary carcinoma 5769, 10 to 15 days; and for solid Erlich ascites tumor, 6 to 8 days after inoculation. Both mammary carcinomas were spontaneous in Strain A mice obtained from the Halsted Laboratories at the University of Colorado. Drug response was determined by measuring with calipers and com paring tumor volumes in the treated animals with those in the controls. Re sults were evaluated as follows: Excellent, indicates a control volume 10 times or more that of the treated group; Good, from 6 to 10 times; Fair, from 2 to 6 times; and Poor, two times or less.