Successful treatment of Bowen's disease with topical maxacalcitol.

نویسندگان

  • Tadashi Karashima
  • Keiko Hashikawa
  • Fumitake Ono
  • Hironobu Eguchi
  • Takahiro Hamada
  • Norito Ishii
  • Teruki Dainichi
  • Shinichiro Yasumoto
  • Daisuke Tsuruta
  • Takashi Hashimoto
چکیده

© 2012 The Authors. doi: 10.2340/00015555-1294 Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Since Bowen’s disease, an intraepidermal squamous cell carcinoma, occurs frequently in elderly people, surgical treatment is sometimes difficult. Therefore, an alternative treatment is required due to other underlying diseases. We report here the case of an elderly man with Bowen’s disease who declined surgical treatment due to concerns of postoperative bleeding secondary to anticoagulation. Occlusive dressing therapy with maxacalcitol, an active vitamin D3 derivative, resulted in clinical resolution. We investigated the mechanism of anti-tumour activity of this vitamin D3 ointment in Bowen’s disease.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Bowen’s disease – a review of newer treatment options

Bowen's disease (squamous cell carcinoma in situ) has a 3%-5% risk to develop into invasive squamous cell carcinoma. Non-melanoma skin cancer is the most common cancer among Caucasians and its incidence has increased during the last decades dramatically. Multiple treatment options for Bowen's disease have been described and are established with advantages and disadvantages. Bowen's disease occu...

متن کامل

Long-term recurrence of nonmelanoma skin cancer after topical methylaminolevulinate photodynamic therapy in a dermato-oncology department.

BACKGROUND Most available studies on the efficacy of topical photodynamic therapy focus on short-to medium-term results. Long-term data are scarce. OBJECTIVE To evaluate the long-term efficacy of photodynamic therapy with topical methylaminolevulinate to treat Bowen's disease and basal cell carcinoma in the clinical practice setting of a dermato-oncology department. METHODS The study includ...

متن کامل

Recurrent Bowen's disease of scalp treated with high dose rate surface mold brachytherapy: a case report and review of the literature

Our case is a 46-year-old female presenting to us with Bowen's disease of scalp since 5 years. Patient had failed topical therapy with 5% 5-florouracil, 0.1% tacrolimus and was intolerant to topical imiquimod. At presentation, she had 15 cm × 10 cm erythematous, hyperpigmented, crusted plaque with irregular border in the superior and lateral aspect of left side of scalp with extension in to for...

متن کامل

Successful treatment of major pemphigus vulgaris relapse with mycophenolate mofetil and high-potent topical corticosteroid

Background: Pemphigus vulgaris (PV) is an autoimmune bullous disorder that is fatal if left untreated. High dose systemic corticosteroids are the basis of therapy. The addition of immunosuppressive agents has improved the disease outcome and reduced the required corticosteroid dose and related toxicity. Mycophenolate mofetil is increasingly used as a steroid-sparing agent in immunotherapy of PV...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Acta dermato-venereologica

دوره 92 6  شماره 

صفحات  -

تاریخ انتشار 2012