Antitoxin activity of Mucuna pruriens aqueous extracts against Cobra and Krait venom by in vivo and in vitro methods
نویسندگان
چکیده
Aqueous extracts of Mucuna pruriens seeds were tested for their activity on various pharmacological effects like lethality, phospholipase activity, edema forming activity, fibrinolytic activity and haemorrhagic activity of of cobra and krait venoms. The aqueous extract displayed a significant inhibitory effect on the lethality, phospholipase activity, edema forming activity, fibrinolytic activity and haemorrhagic activity. About 0.16 mg and 0.19 mg of Mucuna pruriens seed extracts were able to completely neutralize the lethal activity of 2LD50 of cobra and krait venom respectively. The present finding suggests that aqueous extracts of Mucuna pruriens seeds possess compounds, which inhibit the activity of cobra and krait venoms.
منابع مشابه
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Mucuna pruriens has been used by native Nigerians as a prophylactic for snakebite. The protective effects of M. pruriens seed extract (MPE) were investigated against the pharmacological actions of N. sputatrix (Javan spitting cobra) venom in rats. The results showed that MPE-pretreatment protected against cardiorespiratory and, to a lesser extent, neuromuscular depressant effects of N. sputatri...
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