Simultaneous Derivative Spectrophotometric Determination of Levodopa and Carbidopa in Pharmaceutical Preparations
نویسندگان
چکیده
The present work reports on the investigations based on the interaction of sodium hydroxide with catechol derivatives. The first derivative spectra allowed the simultaneous determination of levodopa and carbidopa. The calibration graph was constructed from the first derivative signals by measuring D at 350 nm for standard samples containing between 3 and 30 mg L−1 of levodopa and at 305 nm for standard samples containing between 3 and 80 mg L−1 of carbidopa. This method offers the advantages of simplicity, rapidity, selectivity and higher sensitivity than most of the existing spectophotometric methods.
منابع مشابه
Simultaneous spectrophotometric determination of carbidopa and levodopa by partial least squares regression, principal component regression and least squares support vector machine methods
Three chemometric methods; partial least squares regression (PLS), principal component regression (PCR) and least-squares support vector machines (LS-SVM) were applied for simultaneous determination of carbidopa and levodopa in synthetic mixtures and real samples. The simultaneous determination of these drugs is a difficult problem due to spectral interferences. The proposed methods were used f...
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