Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae.
نویسندگان
چکیده
A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal gene bla(SHV-56), encoding a new inhibitor-resistant beta-lactamase with a pI of 7.6. SHV-56 is derived from SHV-11 by the single substitution K234R. This mutation therefore evidences a new critical site for inhibitor resistance among SHV enzymes.
منابع مشابه
THE FREQUENCY OF TEM, SHV, AND OXA GENES AMONG EXTENDED-SPECTRUM BETA-LACTAMASE PRODUCING KLEBSIELLA PNEUMONIAE AND ESCHERICHIA COLI OBTAINED FROM KIDNEY TRANSPLANT PATIENTS
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 52 10 شماره
صفحات -
تاریخ انتشار 2008