LYMPHOID NEOPLASIA MHC variation and risk of childhood B-cell precursor acute lymphoblastic leukemia
نویسندگان
چکیده
1Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom; 2Department of Statistics, Oxford, United Kingdom; 3Yorkshire Regional Genetic Service, St James University Hospital, Leeds, United Kingdom; 4Department of Paediatric and Adolescent Oncology and Haematology, St James University Hospital, Leeds, United Kingdom; 5Epidemiology and Genetics Unit, Department of Health Sciences, University of York, York, United Kingdom; 6Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom; 7Cancer Immunogenetics Group, School of Cancer & Enabling Sciences, University of Manchester, St Mary’s Hospital, Manchester, United Kingdom; and 8Section of Haemato-oncology, Institute of Cancer Research, Sutton, Surrey, United Kingdom
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Diversity of T-cell receptor Gene Rearrangements in South Indian Patients with Common Acute Lymphoblastic Leukemia
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A role for specific human leukocyte antigen (HLA) variants in the etiology of childhood acute lymphoblastic leukemia (ALL) has been extensively studied over the last 30 years, but no unambiguous association has been identified. To comprehensively study the relationship between genetic variation within the 4.5 Mb major histocompatibility complex genomic region and precursor B-cell (BCP) ALL risk...
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