Comparative Bioavailability of Coenzyme Q10 in Four Formulations

oenzyme Q10 (CoQ10) plays an essential role in mitochondrial electron transport, and as such it is fundamental for energy production in cells. Further, CoQ10 is an antioxidant whose activity is particularly important in regenerating vitamin E. Its ability to quench free-radicals also helps maintain the structural integrity and stability of mitochondrial and cellular membranes—including intracellular membranes. Studies have shown therapeutic benefits for CoQ10 supplementation, the best documented of which involve cases of heart failure and ischemic heart disease. Because CoQ10 is a lipidsoluble nutrient, its bioavailability from pharmaceutical and nutritional products can be limited. USANA uses a patented solubilization system in its current CoQuinone product, which is highly effective in promoting high CoQ10 absorption. However, many of the solubilizing ingredients are synthetic, and ideally an all-natural formula would be preferable. This study was designed to compare the bioavailability of CoQ10 as delivered by four formulas, including a new, proprietary, all-natural formula developed by USANA scientists.