Advancing Survivors' Knowledge (ASK) about skin cancer study: A randomized intervention within the Childhood Cancer Survivor Study (CCSS).

255 Background: Adult survivors of childhood cancer who received radiation therapy have high rates of basal cell carcinoma and melanoma compared with the general population. Both the National Cancer Institute and Children's Oncology Group Guidelines recommend regular skin self-checks and annual clinical skin exams for survivors. The ongoing ASK randomized intervention trial aims to identify strategies, including use of mobile health technology, which may improve early detection practices. METHODS Participants previously treated with radiation and had no previous history of skin cancer were identified, and eligible participants are currently being enrolled. 800 participants are being randomized into: (1) patient activation and education (PAE) including targeted print and web-based materials and monthly text messages prompting skin checks and driving participants to the ASK website; (2) PAE + physician activation (PAE + MD) adding targeted physician activation/educational materials about survivors' increased skin cancer risk and recommendations for conducting full-body skin examinations; (3) PAE + MD + teledermoscopy (PAE + MD +TD). The TD group receives a dermatoscope that attaches to their smartphone to photograph suspect moles for review by the study dermatologist. RESULTS To date, 1,302 survivors are eligible. In the first five months of recruitment, 80% of the initial 400 eligible participants have responded to the study invitation and 248 participants (62%) have enrolled. Twenty-six percent of participants have visited the website and 12 images of suspicious moles have been submitted for review. Completion of recruitment is anticipated by spring 2016. CONCLUSIONS The ASK study addresses screening barriers by providing educational and motivational information for both survivors and physicians on the value of regular and thorough skin examinations. It also determines whether use of innovative mobile health technology activates survivors to conduct skin self-examinations, request physician examinations, and obtain treatment when worrisome lesions are found. CLINICAL TRIAL INFORMATION NCT 02046811.