Pathogenesis of Dengue Thrombocytopenia: Prospective Challenges for Researchers

The incidence of dengue has grown dramatically around the world in recent decades. Over 2.5 billion people – over 40% of the world’s population – are now at risk from dengue. WHO currently estimates there may be 50-100 million dengue infections worldwide every year. Dengue Haemorrhagic Fever (DHF) affects most Asian and Latin American countries and has become a leading cause of hospitalization and death among children in these regions. There continues to be little emphasis on fundamental research on the genetic susceptibility of the host, pathogenesis of Dengue virus (DENV) associated thrombocytopenia, bleeding and plasma leakage [1].