Abate and Switch: miR-145 in Stem Cell Differentiation
نویسندگان
چکیده
MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program.
منابع مشابه
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ورودعنوان ژورنال:
- Cell
دوره 137 شماره
صفحات -
تاریخ انتشار 2009