Pns140 321..326
نویسندگان
چکیده
It is now apparent that one key factor determining the current obesity epidemic within the developed world is the extent to which adipose tissue growth and function can be reset in early life. Adipose tissue can be either brown or white, with brown fat being characterised as possessing a unique uncoupling protein (uncoupling protein 1) that enables the rapid generation of heat by non-shivering thermogenesis. In large mammals this function is recruited at approximately the time of birth, after which brown fat is lost, not normally reappearing again throughout the life cycle. The origin and developmental regulation of brown fat in large mammals is therefore very different from that of small mammals in which brown fat is retained throughout the life cycle and may have the same origin as muscle cells. In contrast, white adipose tissue increases in mass after birth, paralleled by a rise in glucocorticoid action and macrophage accumulation. This process can be reset by changes in the maternal nutritional environment, with the magnitude of response being further determined by the timing at which such a challenge is imposed. Importantly, the long-term response within white adipocytes can occur in the absence of any change in total fat mass. The present review therefore emphasises the need to further understand the developmental regulation of the function of fat through the life cycle in order to optimise appropriate and sustainable intervention strategies necessary not only to prevent obesity in the first place but also to reverse excess fat mass in obese individuals.
منابع مشابه
A Complete Bibliography of Publications in the International Journal on Software Tools for Technology Transfer (STTT)
abduction [661]. abort [422]. abort-aware [422]. ABS [455]. Abstract [435, 620, 132, 419, 481, 425, 131, 122, 551]. Abstraction [597, 182, 489, 621, 323, 382, 123, 429, 359, 205, 326, 234, 407, 385, 325, 510, 40, 426]. abstraction-based [326, 325]. Abstraction-guided [489]. abstraction-refinement [407]. abstraction/refinement [359]. abstractions [406, 217, 618, 664, 321]. ABZ [642]. acceleratio...
متن کاملBiodrugs 2008; 22 (5): 315-329
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متن کاملU . S . Patent Oct . 24 , 2006 SLURRY - METHANOL Sheet 1 of 2 MGA US
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TOM1 and its related proteins, TOM1-like1 (TOM1-L1) and TOM1-like2 (TOM1-L2), constitute a subfamily of the VHS domain protein family. We have recently shown that endofin, a FYVE domain protein associated with the early endosome, is able to recruit cytosolic TOM1 onto endosomal membranes. To reveal the biological consequence of endofin-mediated endosomal recruitment of TOM1, we have identified ...
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