Drosophila GSTs display outstanding catalytic efficiencies with the environmental pollutants 2,4,6-trinitrotoluene and 2,4-dinitrotoluene
نویسندگان
چکیده
The nitroaromatic explosive 2,4,6-trinitrotoluene (TNT) and the related 2,4-dinitrotoluene (DNT) are toxic environmental pollutants. The biotransformation and detoxication of these persistent compounds in higher organisms are of great significance from a health perspective as well as for the biotechnological challenge of bioremediation of contaminated soil. We demonstrate that different human glutathione transferases (GSTs) and GSTs from the fruit fly Drosophila melanogaster are catalysts of the biotransformation of TNT and DNT. The human GSTs had significant but modest catalytic activities with both DNT and TNT. However, D. melanogaster GSTE6 and GSTE7 displayed outstanding high activities with both substrates.
منابع مشابه
Studies on Human and Drosophila melanogaster Glutathione Transfer- ases of Biomedical and Biotechno- logical Interest
Parts of this thesis are based on a previous licentiate thesis v To the martyrs of APS attack, Peshawar vi vii Identification of new inhibitors for human hematopoietic prostaglandin D2 synthase among FDA-approved drugs and other compounds, Chem Biol Interact 229 (2015) 91-99. Overexpression of glutathione transferase E7 in Drosophila differentially impacts toxicity of organic isothiocyanates in...
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