Highly Potent, Chemically Stable Quorum Sensing Agonists for Vibrio Cholerae.
نویسندگان
چکیده
In the Vibrio cholerae pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist of V. cholerae quorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence in V. cholerae.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical science
دوره 5 1 شماره
صفحات -
تاریخ انتشار 2014