Gentamicin Sulfate Assay by HPLC with Charged Aerosol Detection
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چکیده
Introduction Aminoglycoside antibiotics are proven medications for both human and veterinary use with broad-spectrum activity, particularly against gram negative bacteria.1 Many of these antibiotics are manufactured by bacterial culture (fermentation) processes, and as such can be a mixture of active compounds and not a single chemical compound. One example of an antibiotic manufactured by fermentation is gentamicin, an aminoglycoside antibiotic that is produced by Micromonospora echinospora (Micromonospora purpurea). Gentamicin sulfate is a mixture of four major compounds: gentamicins C1, C1a, C2, and C2a. Additionally, gentamicin C2b is commonly present as a minor component. These gentamicin congeners are closely related structurally, as summarized in Figure 1.
منابع مشابه
Determination of Gentamicin Sulphate Composition and Related Substances in Pharmaceutical Preparations by LC with Charged Aerosol Detection
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تاریخ انتشار 2012