Formulation and Optimization of Ciprofloxacin Ocular Liposomal Hydrogel

Conventional ophthalmic dosage forms have lower bioavailability due to many factors like precorneal loss factor, tear dynamics, low residence time etc. Another reason for lower bioavailability is lower permeation of conventional dosage form. This research is based on formulation of liposomal suspension to increase the lipophilic cornea. This liposomal suspension was converted in to hydogel using carbopol 934 to increase residence time. Ciprofloxacin is broad – spectrum antibiotic effective against many Gram-positive and Gram-negative bacteria. Distearoylphosphatidylcholine (DSPC) is synthetic lipid which gives more stability to liposome as compare to natural lipid. The research work started with optimization of processing factors like CH: DSPC ratio, rotating speed, hydration time, drying time, hydration volume and drying temperature. Liposome characterization was done using scanning electron microscopy (SEM). Diffusion study was carried out for comparison between liposomal suspension and hydrogel.