Strontium ranelate: a new alternative treatment for postmenopausal osteoporosis
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منابع مشابه
Strontium ranelate in postmenopausal osteoporosis treatment: a critical appraisal
Osteoporosis is a progressive and debilitating disease characterized by a massive bone loss with a deterioration of bone tissues, and a propensity for a fragility fracture. Strontium ranelate is the first antiosteoporotic treatment that has dual mode of action and simultaneously increases bone formation, while decreasing bone resorption, thus rebalancing bone turnover formation. Strontium ranel...
متن کاملA new contralateral atypical femoral fracture despite sequential therapy with teriparatide and strontium ranelate
Atypical femoral fractures (AFFs) are a rare association of anti-resorptive therapy for osteoporosis. Limited evidence-based management guidelines on their optimal treatment exist, with observational studies suggesting a role for teriparatide (TPTD) in AFF healing. We report a case of a 65-year-old woman with postmenopausal osteoporosis who sustained an AFF following long-term bisphosphonate th...
متن کاملEfficacy of Strontium Ranelate in Combination with a D-Hormone Analog for the Treatment of Postmenopausal Osteoporosis
BACKGROUND Vitamin D supplements are recommended in individuals with vitamin D insufficiency and established osteoporosis to reduce risk of fracture and falling. Active vitamin D metabolites have been found to be more effective for fall prevention than native vitamin D. OBJECTIVES The aim of this study was to compare the efficacy of strontium ranelate in combination with alfacalcidol and stro...
متن کاملStrontium ranelate: a novel treatment for postmenopausal osteoporosis: a review of safety and efficacy
Strontium ranelate is a new orally administered agent for the treatment of women with postmenopausal osteoporosis that reduces the risk of vertebral and hip fractures. Evidence for the safety and efficacy of strontium ranelate comes from two large multinational trials, the SOTI (Spinal Osteoporosis Therapeutic Intervention) and TROPOS (Treatment Of Postmenopausal Osteoporosis) studies. The SOTI...
متن کاملImprovement in bone strength parameters. The role of strontium ranelate.
Strontium ranelate (SR) is a novel anti-osteoporotic agent approved for the treatment of postmenopausal osteoporosis. SR appears to reduce bone resorption by decreasing osteoclast differentiation and activity, and to stimulate bone formation by increasing replication of pre-osteoblast cells, leading to increased matrix synthesis. The effect of SR on bone strength indices has been investigated i...
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