THROMBOSIS AND HEMOSTASIS Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice
نویسندگان
چکیده
1Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford, United Kingdom; 2Center for Thrombosis Research, Florida Hospital, Orlando, FL; 3Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women’s Health, Albert Einstein College of Medicine, New York, NY; and 4Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA
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Intrinsic pathway of coagulation and arterial thrombosis.
Formation of a fibrin clot is mediated by a group of tightly regulated plasma proteases and cofactors. While this system is essential for minimizing blood loss from an injured blood vessel (hemostasis), it also contributes to pathologic fibrin formation and platelet activation that may occlude vessels (thrombosis). Many antithrombotic drugs target key elements of the plasma coagulation mechanis...
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