Symmetry breaking and adaptation: evidence from a 'toy model' of a virus.

نویسندگان

  • J M Vargas
  • C R Stephens
  • H Waelbroeck
  • F Zertuche
چکیده

We argue that an induced breaking of the genetic synonym symmetry due to the action of genetic operators such as mutation can enhance the adaptability of a species to changes in the environment. In the case of a virus, the claim is that the codon bias in the neutralization epitope improves the virus' ability to generate mutants that evade the induced immune response. We support our claim with a simple 'toy model' of a viral epitope evolving in competition with the immune system. The effective selective advantage of a higher mutability leads to a dominance of codons that favor non-synonymous mutations. As further evidence we present a simple model for a genetic regulatory network that leads to adaptive evolution in a population of giraffes by means of an induced symmetry breaking rather than through any direct selective advantage.

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عنوان ژورنال:
  • Bio Systems

دوره 51 1  شماره 

صفحات  -

تاریخ انتشار 1999